通讯作者: 周林, zj_5743@163.com

DOI：10.12201/bmr.202409.00043

The value of serum GP73 combined with prognostic nutritional index in the assessment of prognosis after TACE in HCC patients

• 摘要：【】目的 探讨血清高尔基体蛋白73(GP73)联合预后营养指数(PNI)对肝细胞癌(HCC)患者经动脉化疗栓塞(TACE)术后预后的评估价值。方法 选取2020年1月～2023年1月在我院接受TACE术的HCC患者231例(HCC组)和同时间段120名体检健康者(对照组),根据TACE术后1年预后(肿瘤进展或死亡)将HCC患者分为不良预后组(81例)和良好预后组(150例),检测GP73和计算PNI。以HCC患者TACE术后预后为因变量,建立多因素非条件Logistic回归模型分析其影响因素,并绘制ROC曲线评价血清GP73联合PNI对HCC患者TACE术后预后不良的评估价值。结果 与对照组比较,HCC组血清GP73水平升高,PNI降低(P＜0.05)。随访1年,231例HCC患者TACE术后不良预后发生率为35.06%(81/231)。与良好预后组比较,不良预后组血清GP73水平升高,PNI降低(P＜0.05)。Child-Pugh分级B级、中国肝癌分期Ⅲa期、血管侵犯、GP73高为HCC患者TACE术后不良预后的独立危险因素,PNI高为独立保护因素(P＜0.05)。血清GP73联合PNI评估HCC患者TACE术后不良预后的曲线下面积为0.870,大于血清GP73和PNI单独评估的0.784、0.790(P＜0.05)。结论 HCC患者血清GP73水平升高和PNI降低,是TACE术后不良预后的独立影响因素,血清GP73联合PNI对HCC患者TACE术后不良预后的评估价值较高。

   

  Abstract: 【】Objective To investigate the value of serum Golgi protein 73 (GP73) combined with prognostic nutritional index (PNI) in assessing the prognosis of patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods 231 HCC patients who underwent TACE in our hospital from January 2020 to January 2023 (HCC group) and 120 physically examined healthy people in the same time period (control group) were selected, and the HCC patients were divided into a poor prognosis group (81 patients) and a good prognosis group (150 patients) according to the 1-year prognosis (tumor progression or death) after TACE, and the GP73 was detected and the PNI was calculated. A multifactorial unconditional logistic regression model was established to analyze the influencing factors with TACE postoperative prognosis of HCC patients as the dependent variable, and ROC curves were plotted to evaluate the value of serum GP73 combined with PNI in assessing the poor postoperative prognosis of TACE in HCC patients. Results Compared with the control group, serum GP73 level was increased and PNI was decreased in the HCC group (P＜0.05). At 1-year follow-up, the incidence of poor prognosis after TACE in 231 HCC patients was 35.06% (81/231). Compared with the good prognosis group, the serum GP73 level was increased and PNI was decreased in the poor prognosis group (P＜0.05). Child-Pugh classification grade B, Chinese liver cancer stage IIIa, vascular invasion, and high GP73 were independent risk factors for poor prognosis after TACE in HCC patients, and high PNI was an independent protective factor (P＜0.05). The area under the curve of serum GP73 combined with PNI for assessing poor prognosis after TACE in patients with HCC was 0.870, which was greater than that of serum GP73 and PNI levels assessed alone, which were 0.784 and 0.790 (P＜0.05). Conclusion Elevated serum GP73 levels and reduced PNI in HCC patients are independent influences on poor prognosis after TACE, and serum GP73 combined with PNI has a high value in assessing poor prognosis after TACE in HCC patients.

  提交时间：2024-09-22

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• 序号	提交日期	编号	操作
  1	2024-08-01	10.12201/bmr.202409.00043V1	下载

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