liuyawen, xuqide, hanyi, wuzuoyan, aaa, aaaa, aaaaa, aaaaa, aaaa, aaaa, aaaaa, aaaa, aaaa, aaaa. Evaluation of the efficacy of Linalotide combined with PEG in the bowel preparation for colonoscopy of patients with chronic constipation. 2024. biomedRxiv.202411.00023
Evaluation of the efficacy of Linalotide combined with PEG in the bowel preparation for colonoscopy of patients with chronic constipation
Corresponding author: wuzuoyan, wuzuoyan118@aliyun.com
DOI: 10.12201/bmr.202411.00023
-
Abstract: ObjectiveTo explore the application of linaclotide combined with compound polyethylene glycol electrolyte powder ( PEG) in bowel preparation for colonoscopy of patients with chronic constipation. Methods A toltal of 190 patients with chronic constipation who enderwent electronic colonoscopy in Beijing Sixth Hospital from January to October 2023 were selected as the research objects.The patients were randomized to 3L PEG group (3L PEG), linaclotide group ( linaclotide combined with 3L PEG), and 4L PEG group (4L PEG).The application effects of the three groups were compared. Results The total score of Boston Bowel Preparation Scale(BBPS) in linaclotide group was higher than that in 3L PEG group and 4 PEG group ,and the difference was statistically significant(P<0. 05) .The qualified rate of intestinal cleaning in linaclotide group was higher than that in 3L PEG group(P<0.05),and the incidence of adverse reactions and the willingness to repeat were no statistically significant difference between two groups(P>0.05).The qualified rate of intestinal cleaning and the willingness to repeat in linaclotide group were higher than that in 4L PEG group(P<0.05),and the incidence of adverse reactions was lower than that in 4 PEG group (P<0.05).The qualified rate of intestinal cleaning in 4L PEG group was higher than that in 3L PEG group(P<0.05),however, the incidence of adverse reactions was higher than in 3PEG group(P<0.05),and the willingness to repeat was lower than in 3PEG group(P<0.05).Conclusion Linaclotide combined with PEG can not only improve the intestinal cleaning quality of patients with constipation, but also do not increase the adversereactions of patients, which is suitable for clinical application of patients with chronic constipation.
Key words: linaclotide; PEG; bowel preparation; chronic constipation;Submit time: 11 November 2024
Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity. -
图表
-
zhou bin. Acute urethral obstruction caused by urinary tract infection induced by pegylated interferon alpha in the treatment of chronic hepatitis b: a case report. 2024. doi: 10.12201/bmr.202408.00052
ZHU yan, ZHENG Jie, Li Xiaoying, Yang Xiaolin, HE Yongqun. Introduction to Basic Formal Ontology and its Chinese Translation. 2020. doi: 10.12201/bmr.202007.00009
FU Jinxiang. Application of regulating qi in treating senile constipation. 2024. doi: 10.12201/bmr.202410.00041
fengfengxiang, renhuiling, wangjunhui, caimiaozhi, zhaojiawei, wangweijie. Qualitative systematic evaluation of influencing factors and avoidance strategies of health information avoidance behavior in patients with chronic diseases. 2022. doi: 10.12201/bmr.202207.00017
HUANG Yu-mei, GUAN Li-zheng, SUN Li-guang, CHEN Rui, HAN You-li, WANG Ya-dong, ZHANG Ning, ZENG Yan-bing, MA Cheng-yu, LI Ying. Study on the construction of evaluation index system for multisectoral cooperation in chronic disease prevention and control under the strategy of Healthy China. 2024. doi: 10.12201/bmr.202407.00014
yaojiaqi. Comprehensive evaluation of half dose ticagrelor in the treatment of ACS patients after PCI. 2024. doi: 10.12201/bmr.202407.00070
Qiu Junna. Study and practice on the basic data set of blood composition preparation. 2021. doi: 10.12201/bmr.202108.00007
wang xiangming. Application of holistic functional teaching in clinical teaching of chronic kidney disease. 2024. doi: 10.12201/bmr.202406.00016
niu jifei, hediqiong, yuanqin, wumaofu, huangshunyuan. SWOT Analysis of Chronic Diseases Prevention and Control from the Perspective of New Quality Productivity. 2024. doi: 10.12201/bmr.202411.00069
LiYuan, MaJianling, ShiLiqing, HaoSuying, WangLiyun, LuoJingshu, GuoZhaodi. Progress in the study of the use of conscious sedation techniques in bronchoscopy. 2024. doi: 10.12201/bmr.202409.00030
-
ID Submit time Number Download 1 2024-08-29 bmr.202411.00023V1
Download -
-
Public Anonymous To author only
Get Citation
Article Metrics
- Read: 70
- Download: 0
- Comment: 0