Exploring the mechanism of Xiaochaihu Decoction in treating cough variant asthma (CVA) based on network pharmacology and animal experiments

Corresponding author: lvjiling, lvjiling1980@163.com

DOI: 10.12201/bmr.202510.00009

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  Abstract: Objective Given the limitations of existing therapies for cough variant asthma (CVA), this study systematically explored the mechanisms of Xiaaihu Decoction (XCHD) in the treatment of CVA by combining network pharmacology prediction and animal experiment validation. Methods The active ingredients and potential targets of XD were screened using databases, as well as the targets of CVA-related diseases. A protein interaction network of drug-component-disease-target was constructed, and pathway enrichment analysis was performed. Ovalbumin (OVA)-induced CVA mouse model was established to evaluate the effects of XCHD on pathological changes in lung tissue and the levels of serum inflammatory factors Results A total of 198 potential active ingredients and 212 common drug-disease targets were screened. Core active ingredients may play a role through the intervention of helper 17 cell (Th17) differentiation, interleukin-17 (IL-17) and other signaling pathways. Animal experiments showed that XCH significantly reduced the infiltration of inflammatory cells and tissue damage in the lungs and significantly reduced the levels of serum IL-6, IL-17 and Immunoglobulin E (IgE) (P < 0.05). Conclusion XCHD has the characteristics of multiple components-multiple targets-multiple pathways syneristic effects in the treatment of CVA. Its mechanism may involve regulating IL-6/signal transducer and activator of transcription 3 (STAT3) and IL-7 signaling pathways, reducing airway inflammation and lowering IgE levels.

  Key words: Network pharmacology; Xiaochaihu Decoction; Cough variant asthma (CVA); IL-6; IL-17; IgE

  Submit time: 7 October 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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