The impact of spleen-invigorating and fetus-stabilizing prescription combined with Western medicine therapy on angiopoietin-1, angiopoietin-2, and blood homocysteine levels in patients with fetal growth restriction

Corresponding author: 李苍宁, 1292862257@qq.com

DOI: 10.12201/bmr.202502.00038

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  Abstract: Objective: To evaluate the impact of the spleen-invigorating and fetus-stabilizing prescription combined with Western medicine therapy on the levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and blood homocysteine (Hcy) in patients with fetal growth restriction (FGR), and to explore its regulatory effects on fetal growth and placental hemodynamics.Methods: This study is a prospective randomized controlled clinical trial involving 66 patients with fetal growth restriction (FGR). The patients were randomly divided into a combined treatment group (treated with Jianpi Gutai Prescription in combination with conventional Western medicine) and a control group (treated with conventional Western medicine alone). Levels of Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), and Homocysteine (Hcy), fetal growth indicators, and placental hemodynamic parameters were assessed at baseline, 4 weeks of treatment, 8 weeks of treatment, and at delivery. Data were statistically analyzed using SPSS 26.0, with comparisons between groups conducted using independent-sample t-tests and chi-square tests. Results: After 8 weeks of treatment and at delivery, the levels of Ang-1 and Ang-2 in the combined treatment group were significantly higher than those in the control group, while the level of Hcy was significantly lower than that in the control group (P<0.05). The fetal head circumference, abdominal circumference, femur length, and estimated fetal weight were significantly better in the combined treatment group compared to the control group (P<0.05). There were also significant improvements in the umbilical artery S/D ratio and MCA-PI in the combined treatment group (P<0.05). There were no significant differences in the incidence and severity of adverse reactions between the two groups (P>0.05).Conclusion: The combined treatment of Jianpi Gutai Prescription (a traditional Chinese medicine prescription for strengthening spleen and securing fetus) and Western medicine for patients with fetal growth restriction (FGR) demonstrates significant efficacy. It not only reduces homocysteine (Hcy) levels but also improves placental blood flow and fetal growth in FGR patients, thus warranting clinical promotion.

  Key words: Fetal Growth Restriction; Jianpi Gutai Prescription; Angiopoietin; Blood Homocysteine

  Submit time: 20 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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