通讯作者: 尹剑飞, 520yinjianfei@163.com

DOI：10.12201/bmr.202609.00003

Sun Li1 Yin Jianfei1 Chen Hailu2 Yan Jun1 Wang Qing1 Jiang Feng1 Liu Zheng11 Department of Pediatrics, Xiangdong Hospital Affiliated to Hunan Normal University, Liling, Hunan 412200, China

• 摘要：【】目的：探讨血清克拉拉细胞分泌蛋白16（Clara cell secretory protein 16，CC16）联合炎症指标对儿童重症肺炎支原体肺炎（severe Mycoplasma pneumoniae pneumonia，SMPP）发生的早期预测价值。方法：选取2024年6月—2025年12月本院收治的121例肺炎支原体肺炎（Mycoplasma pneumoniae pneumonia，MPP）患儿为研究对象，根据病程严重程度分为轻症组（87例）与重症组（34例）；同期纳入同年龄段健康体检儿童104例作为健康对照组。收集入组对象入院24h内外周血白细胞(white blood cell，WBC)、CC16、白细胞介素6（interleukin-6，IL-6）、C反应蛋白（C-reactive protein，CRP）、降钙素原（procalcitonin，PCT）、乳酸脱氢酶（lactate dehydrogenase，LDH）等实验室指标，记录患儿氧疗/辅助通气、糖皮质激素、静脉注射免疫球蛋白（intravenous immunoglobulin，IVIG）使用情况、入院退热时长、住院天数等临床资料并进行组间对比；采用Spearman相关分析法分析CC16与各项指标的相关性；通过多因素Logistic回归筛选SMPP独立影响因素；构建受试者工作特征（receiver operating characteristic，ROC）曲线，分别评估单项标志物及联合指标对SMPP的早期预测效能。结果：MPP组患儿血清CC16水平低于健康对照组，且重症组CC16水平显著低于轻症组（均P＜0.001）；血清CC16水平与IL-6、CRP、住院天数呈负相关（均P＜0.001）。多因素Logistic回归提示：CC16降低、IL-6及CRP升高为SMPP发生的独立影响因素（P＜0.05）。ROC结果：CC16、IL-6、CRP单项预测SMPP的曲线下面积（area under the curve，AUC）依次为0.799、0.786、0.844，三项指标联合检测的AUC可达0.950，诊断灵敏度97.1%、特异度83.2%。结论：血清CC16低水平是儿童MPP进展为重症的独立危险因素；CC16联合IL-6、CRP构建的双重评估预测模型诊断效能突出，可用于入院早期快速筛查SMPP高危患儿，指导临床个体化精准治疗。

  关键词： 肺炎支原体肺炎; 儿童; 克拉拉细胞分泌蛋白16; 白细胞介素-6; C反应蛋白; 预测模型

   

  Abstract: 【】Objective: To investigate the early predictive value of serum Clara cell secretory protein 16 (CC16) combined with inflammatory indicators for the development of SMPP in children. Methods: A total of 121 children diagnosed with MPP admitted to our hospital from June 2024 to December 2025 were enrolled as research subjects, and divided into mild group (87 cases) and severe group (34 cases) according to disease severity. Meanwhile, 104 age-matched healthy children receiving physical examination were recruited as the healthy control group. Peripheral blood laboratory indicators including WBC,CC16,IL-6,CRP,PCT and LDH within 24 hours after admission were collected. Clinical data such as oxygen therapy/assisted ventilation, application of glucocorticoids and IVIG, duration of fever after admission and length of hospital stay were recorded for intergroup comparison. Spearman correlation analysis was adopted to analyze the correlation between CC16 and various indicators. Multivariate Logistic regression analysis was performed to screen independent influencing factors of SMPP. ROC curves were plotted to evaluate the early predictive efficacy of single biomarkers and combined indicators for SMPP respectively. Results: Serum CC16 level in MPP group was lower than that in healthy control group, and the severe group had significantly decreased CC16 level compared with the mild group (all P＜0.001). Serum CC16 level was negatively correlated with IL-6, CRP and length of hospital stay (all P＜0.001). Multivariate Logistic regression indicated that reduced CC16, elevated IL-6 and elevated CRP were independent influencing factors for the occurrence of SMPP (P＜0.05). ROC analysis showed that the AUC of CC16, IL-6 and CRP for single prediction of SMPP was 0.799, 0.786 and 0.844 respectively, while the AUC of combined detection of the three indicators reached 0.950, with a diagnostic sensitivity of 97.1% and specificity of 83.2%. Conclusion: Low serum CC16 level is an independent risk factor for the progression of MPP to severe disease in children. The dual evaluation prediction model constructed by CC16 combined with IL-6 and CRP presents outstanding diagnostic efficacy, which can be applied to rapidly screen children at high risk of SMPP at the early stage of admission and guide individualized precise clinical treatment.

  Key words: Mycoplasma pneumoniae pneumonia; children; Clara cell secretory protein 16; interleukin-6; C-reactive protein; predictive model

  提交时间：2026-09-01

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• p>何海玲, 陆建良, 冯媛, 卢艳玲. 儿童重症肺炎支原体肺炎的临床特点分析. 2025. doi: 10.12201/bmr.202505.00038

  施明杰, 叶洪舟, 袁琛. 大环内酯类耐药肺炎支原体肺炎患儿发展为重症肺炎的危险因素分析及预测模型构建. 2024. doi: 10.12201/bmr.202409.00021

  马亚鑫, 朱晓伟, 李淑琼, 李云翔, 孙永红. 儿童重症肺炎支原体肺炎早期预测的研究进展. 2025. doi: 10.12201/bmr.202504.00073

  李会君, 霍洁, 杭菲菲, 徐静, 管峥. 血清IgE、LDH及IL-18对儿童难治性肺炎支原体肺炎的早期识别价值. 2026. doi: 10.12201/bmr.202606.00009

  吕海涛, 沈腾腾, 许会卿, 徐月波, 郑吉善. 多西环素治疗8岁以下儿童肺炎支原体肺炎的疗效分析. 2025. doi: 10.12201/bmr.202509.00001

  时小淋, 汤冬静, 吴美慧. 儿童肺炎支原体支气管肺炎和大叶性肺炎的相关危险因素分析. 2025. doi: 10.12201/bmr.202507.00035

  王媛媛, 常艳美, 于丽娟, 孟淑萍. 肺炎支原体RNA检测在儿童肺炎支原体肺炎诊断和治疗中的价值研究. 2025. doi: 10.12201/bmr.202506.00025

  王美林, 杨鹏丽, 庞高峰, 郭峥. 基于Citespace的中医药治疗肺炎支原体肺炎可视化分析. 2026. doi: 10.12201/bmr.202604.00142

  罗自豪, 耿　刚, 李少军. 儿童肺炎支原体脑炎1例并文献复习. 2024. doi: 10.12201/bmr.202408.00042

  刘嘉欣, 张小华, 杨逸彤. CARDS TX在儿童肺炎支原体感染中的研究进展. 2025. doi: 10.12201/bmr.202506.00057

• 序号	提交日期	编号	操作
  1	2026-06-02	10.12201/bmr.202609.00003V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论