通讯作者: 张富, 22851605@qq.com

DOI：10.12201/bmr.202512.00041

Exploring the Role of Gut Microbiota in the Pathogenesis of Hypertension Based on the

• 摘要：基于《黄帝内经》“脾为之卫”理论,该理论探讨系统阐释了肠道菌群作为关键枢纽连接“脾虚”与高血压的内在机制。通过梳理“脾虚卫弱-邪气犯脉”、“腠理疏松-外邪入里”、“脾虚生痰-痰瘀痹阻”三大病理环节,该论述揭示了肠道菌群失调所介导的全身免疫炎症、屏障损伤及代谢紊乱在高血压发病中的核心作用。这一探讨从微生态视角深化了“脾为之卫”的科学内涵,为从脾胃角度理解高血压病机提供了新的理论框架,为高血压的防治提供新的理论依据与临床思路。

  关键词： 脾为之卫; 肠道菌群; 高血压

   

  Abstract: Based on the spleen acting as defense theory from The Yellow Emperors Inner Classic, this theoretical exploration systematically elucidates the intrinsic mechanism by which gut microbiota serves as a key hub connecting spleen deficiency and hypertension. By examining the three pathological stages—spleen deficiency and weakened defense leading to pathogenic factors attacking the vessels, loose striae allowing external pathogens to invade internally, and spleen deficiency producing phlegm resulting in phlegm-stasis obstruction—the analysis reveals the central role of gut microbiota dysbiosis in mediating systemic immune inflammation, barrier impairment, and metabolic disturbances in the pathogenesis of hypertension. This discussion deepens the scientific understanding of the spleen as defense concept from a microecological perspective, offering a new theoretical framework for interpreting the mechanism of hypertension from the spleen-stomach viewpoint, and provides novel theoretical foundations and clinical insights for its prevention and treatment.

  Key words: Spleen as the Defender; Gut microbiota; Hypertension

  提交时间：2025-12-15

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-11-06	10.12201/bmr.202512.00041V1	下载

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